Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Fanconi anemia (FA) is a rare inherited syndrome characterized by progressive bone marrow failure (BMF), abnormal skin pigmentation, short stature, and increased cancer risk. BMF in FA is multifactorial and largely results from the death of hematopoietic stem cells due to genomic instability. Also,...

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Hlavní autoři: Snehal Shabrish, Madhura Kelkar, Niranjan Chavan, Mukesh Desai, Umair Bargir, Maya Gupta, Priti Mehta, Akanksha Chichra, Chandrakala S, Prasad Taur, Vinay Saxena, Babu Rao Vundinti, Manisha Madkaikar
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019-03-01
Edice:Frontiers in Immunology
Témata:
Fanconi anemia
NK cell degranulation defect
Familial Hemophagocytic lymphohistiocytosis (FHL)
HLH-targeted therapy
NK cell cytotoxicity
On-line přístup:https://www.frontiersin.org/article/10.3389/fimmu.2019.00490/full
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