Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

OBJECTIVE: Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces tau hyperphosphorylation. The 3xTg-AD mouse model not only develops tau and amyloid pathologies in the bra...

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Vydáno v:Mol Metab
Hlavní autoři: Tournissac, Marine, Bourassa, Philippe, Martinez-Cano, Ruben D., Vu, Tra-My, Hébert, Sébastien S., Planel, Emmanuel, Calon, Frédéric
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437631/
https://ncbi.nlm.nih.gov/pubmed/30770297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.01.008
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