Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

Uridine-diphosphate glucuronosyltransferase 1A1 (UGT1A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1A1 may trigger adverse drug/herb–drug interactions, or result in met...

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Vydáno v:Acta Pharm Sin B
Hlavní autoři: Lv, Xia, Xia, Yangliu, Finel, Moshe, Wu, Jingjing, Ge, Guangbo, Yang, Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437557/
https://ncbi.nlm.nih.gov/pubmed/30972276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.09.005
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