A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine

Rifapentine is a rifamycin used to treat tuberculosis. As is the case for rifampin, plasma exposures of rifapentine are associated with the treatment response. While concomitant food intake and HIV infection explain part of the pharmacokinetic variability associated with rifapentine, few studies hav...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Francis, Jose, Zvada, Simbarashe P., Denti, Paolo, Hatherill, Mark, Charalambous, Salome, Mungofa, Stanley, Dawson, Rodney, Dorman, Susan, Gupte, Nikhil, Wiesner, Lubbe, Jindani, Amina, Harrison, Thomas S., Olagunju, Adeniyi, Egan, Deirdre, Owen, Andrew, McIlleron, Helen M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437540/
https://ncbi.nlm.nih.gov/pubmed/30670438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01964-18
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