The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis

Bacteriophage-derived lysins are cell-wall-hydrolytic enzymes that represent a potential new class of antibacterial therapeutics in development to address burgeoning antimicrobial resistance. CF-301, the lead compound in this class, is in clinical development as an adjunctive treatment to potentiall...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Indiani, Chiara, Sauve, Karen, Raz, Assaf, Abdelhady, Wessam, Xiong, Yan Q., Cassino, Cara, Bayer, Arnold S., Schuch, Raymond
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437495/
https://ncbi.nlm.nih.gov/pubmed/30670427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02291-18
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