Impact of polymorphisms within genes involved in regulating DNA methylation in metastatic colorectal cancer patients enrolled in three independent, randomized, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC, and FIRE-3.

BACKGROUND: CpG island DNA hypermethylation and global DNA hypomethylation are hallmark characteristics of CRC. Therefore, we aim to explore the effect of genetic variations within the genes that regulate the DNA methylation and demethylation pathways on outcomes in metastatic CRC (mCRC) patients tr...

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Publicado no:Eur J Cancer
Main Authors: Puccini, Alberto, Loupakis, Fotios, Stintzing, Sebastian, Cao, Shu, Battaglin, Francesca, Togunaka, Ryuma, Naseem, Madiha, Berger, Martin D, Soni, Shivani, Zhang, Wu, Mancao, Christoph, Salhia, Bodour, Mumenthaler, Shannon M, Weisenberger, Daniel J., Liang, Gangning, Cremolini, Chiara, Heinemann, Volker, Falcone, Alfredo, Millstein, Joshua, Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436973/
https://ncbi.nlm.nih.gov/pubmed/30852420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2019.01.105
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