Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in the vast majority of cells; this lack of coverage pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Cell
Hauptverfasser: Rodriguez-Meira, Alba, Buck, Gemma, Clark, Sally-Ann, Povinelli, Benjamin J., Alcolea, Veronica, Louka, Eleni, McGowan, Simon, Hamblin, Angela, Sousos, Nikolaos, Barkas, Nikolaos, Giustacchini, Alice, Psaila, Bethan, Jacobsen, Sten Eirik W., Thongjuea, Supat, Mead, Adam J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436961/
https://ncbi.nlm.nih.gov/pubmed/30765193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.009
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge