Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in the vast majority of cells; this lack of coverage pr...

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I publikationen:Mol Cell
Huvudupphovsmän: Rodriguez-Meira, Alba, Buck, Gemma, Clark, Sally-Ann, Povinelli, Benjamin J., Alcolea, Veronica, Louka, Eleni, McGowan, Simon, Hamblin, Angela, Sousos, Nikolaos, Barkas, Nikolaos, Giustacchini, Alice, Psaila, Bethan, Jacobsen, Sten Eirik W., Thongjuea, Supat, Mead, Adam J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436961/
https://ncbi.nlm.nih.gov/pubmed/30765193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.009
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