Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMM...

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Publicado en:J Exp Med
Main Authors: Louka, Eleni, Povinelli, Benjamin, Rodriguez-Meira, Alba, Buck, Gemma, Wen, Wei Xiong, Wang, Guanlin, Sousos, Nikolaos, Ashley, Neil, Hamblin, Angela, Booth, Christopher A.G., Roy, Anindita, Elliott, Natalina, Iskander, Deena, de la Fuente, Josu, Fordham, Nicholas, O’Byrne, Sorcha, Inglott, Sarah, Norfo, Ruggiero, Salio, Mariolina, Thongjuea, Supat, Rao, Anupama, Roberts, Irene, Mead, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802370/
https://ncbi.nlm.nih.gov/pubmed/33416891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180853
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