Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial resolution of immune cells with laser capture microdissection gene expression profiles, we defined distinct TIME stratificatio...

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Vydáno v:J Clin Invest
Hlavní autoři: Gruosso, Tina, Gigoux, Mathieu, Manem, Venkata Satya Kumar, Bertos, Nicholas, Zuo, Dongmei, Perlitch, Irina, Saleh, Sadiq Mehdi Ismail, Zhao, Hong, Souleimanova, Margarita, Johnson, Radia Marie, Monette, Anne, Ramos, Valentina Muñoz, Hallett, Michael Trevor, Stagg, John, Lapointe, Réjean, Omeroglu, Atilla, Meterissian, Sarkis, Buisseret, Laurence, Van den Eynden, Gert, Salgado, Roberto, Guiot, Marie-Christine, Haibe-Kains, Benjamin, Park, Morag
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436884/
https://ncbi.nlm.nih.gov/pubmed/30753167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96313
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