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Pairing JAK with MEK for improved therapeutic efficiency in myeloproliferative disorders

The identification of JAK2 mutations as disease-initiating in myeloproliferative neoplasms (MPNs) has led to new and effective therapies for these diseases. In a study published in this issue of the JCI, Stivala et al. explored the key observation that JAK inhibition successfully suppresses MAPK act...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Hovedforfatter: Williams, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436870/
https://ncbi.nlm.nih.gov/pubmed/30829649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127582
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