Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-Cre(ERT2) Tgfbr2(fl/fl)...

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書目詳細資料
發表在:J Clin Invest
Main Authors: McCann, James V., Xiao, Lin, Kim, Dae Joong, Khan, Omar F., Kowalski, Piotr S., Anderson, Daniel G., Pecot, Chad V., Azam, Salma H., Parker, Joel S., Tsai, Yihsuan S., Wolberg, Alisa S., Turner, Stephen D., Tatsumi, Kohei, Mackman, Nigel, Dudley, Andrew C.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436861/
https://ncbi.nlm.nih.gov/pubmed/30855280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123106
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