Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-Cre(ERT2) Tgfbr2(fl/fl)...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: McCann, James V., Xiao, Lin, Kim, Dae Joong, Khan, Omar F., Kowalski, Piotr S., Anderson, Daniel G., Pecot, Chad V., Azam, Salma H., Parker, Joel S., Tsai, Yihsuan S., Wolberg, Alisa S., Turner, Stephen D., Tatsumi, Kohei, Mackman, Nigel, Dudley, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436861/
https://ncbi.nlm.nih.gov/pubmed/30855280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123106
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