Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-Cre(ERT2) Tgfbr2(fl/fl)...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: McCann, James V., Xiao, Lin, Kim, Dae Joong, Khan, Omar F., Kowalski, Piotr S., Anderson, Daniel G., Pecot, Chad V., Azam, Salma H., Parker, Joel S., Tsai, Yihsuan S., Wolberg, Alisa S., Turner, Stephen D., Tatsumi, Kohei, Mackman, Nigel, Dudley, Andrew C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436861/
https://ncbi.nlm.nih.gov/pubmed/30855280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123106
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge