Dengue-specific CD8(+) T cell subsets display specialized transcriptomic and TCR profiles

Accumulating evidence demonstrates that CD8(+) T cells contribute to protection from severe dengue virus (DENV) disease and vaccine efficacy. Nevertheless, molecular programs associated with DENV-specific CD8(+) T cell subsets have not been defined. Here, we studied the transcriptomic profiles of hu...

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Vydáno v:J Clin Invest
Hlavní autoři: Tian, Yuan, Babor, Mariana, Lane, Jerome, Seumois, Grégory, Liang, Shu, Goonawardhana, N.D. Suraj, De Silva, Aruna D., Phillips, Elizabeth J., Mallal, Simon A., da Silva Antunes, Ricardo, Grifoni, Alba, Vijayanand, Pandurangan, Weiskopf, Daniela, Peters, Bjoern, Sette, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436856/
https://ncbi.nlm.nih.gov/pubmed/30882366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123726
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