Trapping biosynthetic acyl–enzyme intermediates with encoded 2,3-diaminopropionic acid

Many enzymes catalyse reactions that proceed through covalent acyl–enzyme (ester or thioester) intermediates(1). These enzymes include serine hydrolases(2,3) (encoded by one per cent of human genes, and including serine proteases and thioesterases), cysteine proteases (including caspases), and many...

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Bibliographic Details
Published in:Nature
Main Authors: Huguenin-Dezot, Nicolas, Alonzo, Diego A., Heberlig, Graham W., Mahesh, Mohan, Nguyen, Duy P., Dornan, Mark H., Boddy, Christopher N., Martin Schmeing, T., Chin, Jason W.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436733/
https://ncbi.nlm.nih.gov/pubmed/30542153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0781-z
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