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Trapping biosynthetic acyl–enzyme intermediates with encoded 2,3-diaminopropionic acid

Many enzymes catalyse reactions that proceed through covalent acyl–enzyme (ester or thioester) intermediates(1). These enzymes include serine hydrolases(2,3) (encoded by one per cent of human genes, and including serine proteases and thioesterases), cysteine proteases (including caspases), and many...

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Publicado en:Nature
Autores principales: Huguenin-Dezot, Nicolas, Alonzo, Diego A., Heberlig, Graham W., Mahesh, Mohan, Nguyen, Duy P., Dornan, Mark H., Boddy, Christopher N., Martin Schmeing, T., Chin, Jason W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436733/
https://ncbi.nlm.nih.gov/pubmed/30542153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0781-z
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