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Trapping biosynthetic acyl–enzyme intermediates with encoded 2,3-diaminopropionic acid
Many enzymes catalyse reactions that proceed through covalent acyl–enzyme (ester or thioester) intermediates(1). These enzymes include serine hydrolases(2,3) (encoded by one per cent of human genes, and including serine proteases and thioesterases), cysteine proteases (including caspases), and many...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6436733/ https://ncbi.nlm.nih.gov/pubmed/30542153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0781-z |
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