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Utilization of a depsipeptide substrate for trapping acyl—enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases

The penicillin-sensitive D-alanine carboxypeptidases of Bacillus subtilis, Escherichia coli, and Staphylococcus aureus catalyzed the hydrolysis of the D-lactic acid residue from the depsipeptide diacetyl-L-lysyl-D-alanyl-D-lactic acid. The ester substrate was hydrolyzed faster than the peptide analo...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Rasmussen, James R., Strominger, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1978
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/415311/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.1.84
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