PPARγ Interaction with UBR5/ATMIN Promotes DNA Repairto Maintain Endothelial Homeostasis

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPAR γ) through its interaction with the DNA damage sensor MRE11-RAD50-NBS1 (MRN) and the E3 ubiquitin ligase UBR5. We show that PPAR γ promotes ATM signaling and is essent...

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Publicat a:Cell Rep
Autors principals: Li, Caiyun G., Mahon, Cathal, Sweeney, Nathaly M., Verschueren, Erik, Kantamani, Vivek, Li, Dan, Hennigs, Jan K., Marciano, David P., Diebold, Isabel, Abu-Halawa, Ossama, Elliott, Matthew, Sa, Silin, Guo, Feng, Wang, Lingli, Cao, Aiqin, Guignabert, Christophe, Sollier, Julie, Nickel, Nils P., Kaschwich, Mark, Cimprich, Karlene A., Rabinovitch, Marlene
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436616/
https://ncbi.nlm.nih.gov/pubmed/30699358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.013
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