The CARMA3-Bcl10-MALT1 Signalosome Drives NF-κB Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast Cancer.

The angiotensin II receptor AGTR1, which mediates vasoconstrictive and inflammatory signaling in vascular disease, is overexpressed aberrantly in some breast cancers. In this study, we established the significance of an AGTR1-responsive NF-κB signaling pathway in this breast cancer subset. We docume...

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Udgivet i:Cancer Res
Main Authors: Ekambaram, Prasanna, Lee, Jia-Ying (Lloyd), Hubel, Nathaniel E., Hu, Dong, Yerneni, Saigopalakrishna, Campbell, Phil G., Pollock, Netanya, Klei, Linda R., Concel, Vincent J., Delekta, Phillip C., Chinnaiyan, Arul M., Tomlins, Scott A., Rhodes, Daniel R., Priedigkeit, Nolan, Lee, Adrian V., Oesterreich, Steffi, McAllister-Lucas, Linda M., Lucas, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436094/
https://ncbi.nlm.nih.gov/pubmed/29259013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1089
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