Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease

It has been well documented that neurotrophins, including brain-derived neurotrophic factor (BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a myriad of technical challenges. Here we took advantage of the early astrogliosis observed in an amyloid mouse m...

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Foilsithe in:J Neurosci
Main Authors: de Pins, Benoit, Cifuentes-Díaz, Carmen, Farah, Amel Thamila, López-Molina, Laura, Montalban, Enrica, Sancho-Balsells, Anna, López, Ana, Ginés, Silvia, Delgado-García, José María, Alberch, Jordi, Gruart, Agnès, Girault, Jean-Antoine, Giralt, Albert
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2019
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435824/
https://ncbi.nlm.nih.gov/pubmed/30700530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2121-18.2019
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