Distinct mechanical properties in homologous spectrin-like repeats of utrophin

Patients with Duchenne muscular dystrophy (DMD) lack the protein dystrophin, which is a critical molecular component of the dystrophin-glycoprotein complex (DGC). Dystrophin is hypothesized to function as a molecular shock absorber that mechanically stabilizes the sarcolemma of striated muscle throu...

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Udgivet i:Sci Rep
Main Authors: Rajaganapathy, Sivaraman, McCourt, Jackie L., Ghosal, Sayan, Lindsay, Angus, McCourt, Preston M., Lowe, Dawn A., Ervasti, James M., Salapaka, Murti V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435810/
https://ncbi.nlm.nih.gov/pubmed/30914715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41569-4
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