Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the perspective of the gut microbiota, here, a chronic...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Yu, Jin-Bo, Zhao, Zhen-Xiong, Peng, Ran, Pan, Li-Bin, Fu, Jie, Ma, Shu-Rong, Han, Pei, Cong, Lin, Zhang, Zheng-Wei, Sun, Li-Xin, Jiang, Jian-Dong, Wang, Yan
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435784/
https://ncbi.nlm.nih.gov/pubmed/30949054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00268
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