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IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
IL-9-producing CD4(+) (Th9) cells are a subset of CD4(+) T-helper cells that are endowed with powerful antitumor capacity. Both IL-4 and TGF-β have been reported to be indispensable for Th9 cell-priming and differentiation. Here we show, by contrast, that Th9 cell development can occur in the absenc...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6435687/ https://ncbi.nlm.nih.gov/pubmed/30914642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09401-9 |
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