Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

BACKGROUND: Lactic acidosis with an elevated lactate–pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation. To assess if there is an additional contribution to hyperlact...

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Veröffentlicht in:Malar J
Hauptverfasser: Kingston, Hugh W., Ghose, Aniruddha, Rungpradubvong, Voravut, Herdman, M. Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J., Maude, Richard J., Intharabut, Benjamas, Mohanty, Sanjib, Day, Nicholas P. J., White, Nicholas J., Hossain, Md Amir, Anstey, Nicholas M., Dondorp, Arjen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434797/
https://ncbi.nlm.nih.gov/pubmed/30909915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-2733-y
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