The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa

In the cyclic guanosine monophosphate (cGMP) signaling pathway, phosphodiesterase 6 (PDE6) maintains a critical balance of the intracellular concentration of cGMP by catalyzing it to 5′ guanosine monophosphate (5′-GMP). To gain insight into the mechanistic impacts of the PDE6 somatic mutations that...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Maryam, Arooma, Vedithi, Sundeep Chaitanya, Khalid, Rana Rehan, Alsulami, Ali F., Torres, Pedro Henrique Monteiro, Siddiqi, Abdul Rauf, Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434069/
https://ncbi.nlm.nih.gov/pubmed/30962868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.03.004
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