Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin

Mutations in the mitochondrial GTPase mitofusin 2 (MFN2) cause Charcot-Marie-Tooth disease type 2 (CMT2A), a form of peripheral neuropathy that compromises axonal function. Mitofusins promote mitochondrial fusion and regulate mitochondrial dynamics. They are also reported to be involved in forming c...

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Udgivet i:Cell Death Dis
Main Authors: Garrido-Maraver, Juan, Celardo, Ivana, Costa, Ana C., Lehmann, Susann, Loh, Samantha H. Y., Martins, L. Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433915/
https://ncbi.nlm.nih.gov/pubmed/30911005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1496-2
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