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Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications
Huntington’s disease (HD) is a neurodegenerative disease triggered by expansion of polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and elicits toxicity by multiple mechanisms which range from dysregulated transcription to disturbances in several metabolic pathway...
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| Udgivet i: | Front Mol Neurosci |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433839/ https://ncbi.nlm.nih.gov/pubmed/30941013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00068 |
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