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Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

Huntington’s disease (HD) is a neurodegenerative disease triggered by expansion of polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and elicits toxicity by multiple mechanisms which range from dysregulated transcription to disturbances in several metabolic pathway...

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Bibliografiske detaljer
Udgivet i:Front Mol Neurosci
Main Authors: Paul, Bindu D., Snyder, Solomon H.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433839/
https://ncbi.nlm.nih.gov/pubmed/30941013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00068
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