Whole genome sequencing to characterize monogenic and polygenic contributions in patients hospitalized with early-onset myocardial infarction

BACKGROUND: The relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score (cumulative impact of many common variants) pathways for early-onset myocardial infarction remain uncertain. Whole genome sequencing enables simulta...

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Publicat a:Circulation
Autors principals: Khera, Amit V., Chaffin, Mark, Zekavat, Seyedeh Maryam, Collins, Ryan L., Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Chen, Yii-Der Ida, Talkowski, Michael E., Rotter, Jerome I., Krumholz, Harlan M., Kathiresan, Sekar
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433484/
https://ncbi.nlm.nih.gov/pubmed/30586733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.035658
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