N-terminal methionine excision of proteins creates tertiary destabilizing N-degrons of the Arg/N-end rule pathway

All organisms begin protein synthesis with methionine (Met). The resulting initiator Met of nascent proteins is irreversibly processed by Met aminopeptidases (MetAPs). N-terminal (Nt) Met excision (NME) is an evolutionarily conserved and essential process operating on up to two-thirds of proteins. H...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Nguyen, Kha The, Kim, Jeong-Mok, Park, Sang-Eun, Hwang, Cheol-Sang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Protein Synthesis and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433082/
https://ncbi.nlm.nih.gov/pubmed/30674553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006913
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