Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2

Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is only sparsely expressed on healthy tissue. GD2 is a primary target for the development of immunotherapy for neuroblastoma. Immunotherapy with monoclonal anti-GD2 antibodies has proven saf...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: van den Bijgaart, Renske J. E., Kroesen, Michiel, Wassink, Melissa, Brok, Ingrid C., Kers-Rebel, Esther D., Boon, Louis, Heise, Torben, van Scherpenzeel, Monique, Lefeber, Dirk J., Boltje, Thomas J., den Brok, Martijn H., Hoogerbrugge, Peter M., Büll, Christian, Adema, Gosse J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433061/
https://ncbi.nlm.nih.gov/pubmed/30670592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002763
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