Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

[Image: see text] Metabolic incorporation of azide- or alkyne-modified sialic acids into the cellular glycosylation pathway enables the study of sialoglycan expression, localization, and trafficking via bioorthogonal chemistry. Herein, we report that such modifications of the sialic acid sugar can h...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Heise, Torben, Büll, Christian, Beurskens, Daniëlle M., Rossing, Emiel, de Jonge, Marien I., Adema, Gosse J., Boltje, Thomas J., Langereis, Jeroen D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520103/
https://ncbi.nlm.nih.gov/pubmed/28635265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00224
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