Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

[Image: see text] Metabolic incorporation of azide- or alkyne-modified sialic acids into the cellular glycosylation pathway enables the study of sialoglycan expression, localization, and trafficking via bioorthogonal chemistry. Herein, we report that such modifications of the sialic acid sugar can h...

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Bibliographic Details
Published in:Bioconjug Chem
Main Authors: Heise, Torben, Büll, Christian, Beurskens, Daniëlle M., Rossing, Emiel, de Jonge, Marien I., Adema, Gosse J., Boltje, Thomas J., Langereis, Jeroen D.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520103/
https://ncbi.nlm.nih.gov/pubmed/28635265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00224
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