Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity

Platelets are increasingly recognized to play a role in the complications of Streptococcus pneumoniae infections. S. pneumoniae expresses neuraminidases, which may alter glycans on the platelet surface. In the present study, we investigated the capability of pneumococcal neuraminidase A (NanA) to re...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Kullaya, Vesla, de Jonge, Marien I., Langereis, Jeroen D., van der Gaast-de Jongh, Christa E., Büll, Christian, Adema, Gosse J., Lefeber, Dirk, Cremers, Amelieke J., Mmbaga, Blandina T., de Groot, Phillip G., de Mast, Quirijn, van der Ven, Andre J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204724/
https://ncbi.nlm.nih.gov/pubmed/30037798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00213-18
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