Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization

Angiotensin-converting enzyme (ACE) can hydrolyze many peptides and plays a central role in controlling blood pressure. Moreover, ACE overexpression in monocytes and macrophages increases resistance of mice to tumor growth. ACE is composed of two independent catalytic domains. Here, to investigate t...

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Опубликовано в: :J Biol Chem
Главные авторы: Khan, Zakir, Cao, Duo-Yao, Giani, Jorge F., Bernstein, Ellen A., Veiras, Luciana C., Fuchs, Sebastien, Wang, Yizhou, Peng, Zhenzi, Kalkum, Markus, Liu, George Y., Bernstein, Kenneth E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433053/
https://ncbi.nlm.nih.gov/pubmed/30670595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006275
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