Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization

Angiotensin-converting enzyme (ACE) can hydrolyze many peptides and plays a central role in controlling blood pressure. Moreover, ACE overexpression in monocytes and macrophages increases resistance of mice to tumor growth. ACE is composed of two independent catalytic domains. Here, to investigate t...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Khan, Zakir, Cao, Duo-Yao, Giani, Jorge F., Bernstein, Ellen A., Veiras, Luciana C., Fuchs, Sebastien, Wang, Yizhou, Peng, Zhenzi, Kalkum, Markus, Liu, George Y., Bernstein, Kenneth E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433053/
https://ncbi.nlm.nih.gov/pubmed/30670595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006275
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