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Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products

Approval of generic drugs by the US Food and Drug Administration (FDA) requires the product to be pharmaceutically equivalent to the reference listed drug (RLD) and demonstrate bioequivalence (BE) in effectiveness when administered to patients under the conditions in the RLD product labeling. Effect...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Au, Jessie L.-S., Lu, Ze, Abbiati, Roberto A., Wientjes, M. Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432930/
https://ncbi.nlm.nih.gov/pubmed/30710324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0296-z
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