Bromate-induced Changes in p21 DNA Methylation and Histone Acetylation in Renal Cells

Bromate ([Formula: see text]) is a water disinfection byproduct (DBP) previously shown to induce nephrotoxicity in vitro and in vivo. We recently showed that inhibitors of DNA methyltransferase 5-aza-2′-deoxycytidine (5-Aza) and histone deacetylase trichostatin A (TSA) increased [Formula: see text]...

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Vydáno v:Toxicol Sci
Hlavní autoři: Kolli, Ramya T, Glenn, Travis C, Brown, Bradley T, Kaur, Sukhneeraj P, Barnett, Lillie M, Lash, Lawrence H, Cummings, Brian S
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Bromate and Epigenetic Changes in Renal Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432867/
https://ncbi.nlm.nih.gov/pubmed/30649504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz016
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