Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity

METHODS: Human ARPE-19 cells engineered to secrete high levels of the glial cell line-derived neurotrophic factor (GDNF) were encapsulated into hollow fiber membranes. The devices were implanted into the rat striatum 1 week prior to striatal quinolinic acid injections. Animals were evaluated using a...

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Veröffentlicht in:Neural Plast
Hauptverfasser: Emerich, Dwaine F., Kordower, Jeffrey H., Chu, Yaping, Thanos, Chris, Bintz, Briannan, Paolone, Giovanna, Wahlberg, Lars U.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432730/
https://ncbi.nlm.nih.gov/pubmed/30984255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6286197
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