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Conformationally restricted quinazolone derivatives as PI3Kδ-selective inhibitors: the design, synthesis and biological evaluation
A series of structurally novel quinazolone-based PI3Kδ-selective inhibitors were designed and synthesized via the approach of conformational restriction. The majority of them exhibited two-digit to single-digit nanomolar IC(50) values against PI3Kδ, along with low micromolar to submicromolar GI(50)...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6431952/ https://ncbi.nlm.nih.gov/pubmed/30996859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00556g |
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