Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

Glioblastoma (GBM) is the most lethal primary brain tumor and is highly resistant to current treatments. GBM harbors glioma stem cells (GSCs) that not only initiate and maintain malignant growth but also promote therapeutic resistance including radioresistance. Thus, targeting GSCs is critical for o...

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Pubblicato in:Sci Transl Med
Autori principali: Shi, Yu, Guryanova, Olga A., Zhou, Wenchao, Liu, Chong, Huang, Zhi, Fang, Xiaoguang, Wang, Xiuxing, Chen, Cong, Wu, Qiulian, He, Zhicheng, Wang, Wei, Zhang, Wei, Jiang, Tao, Liu, Qing, Chen, Yaping, Wang, Wenying, Wu, Jingjing, Kim, Leo, Gimple, Ryan C., Feng, Hua, Kung, Hsiang-Fu, Yu, Jennifer S., Rich, Jeremy N., Ping, Yi-Fang, Bian, Xiu-Wu, Bao, Shideng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431250/
https://ncbi.nlm.nih.gov/pubmed/29848664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah6816
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