Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

Glioblastoma (GBM) is the most lethal primary brain tumor and is highly resistant to current treatments. GBM harbors glioma stem cells (GSCs) that not only initiate and maintain malignant growth but also promote therapeutic resistance including radioresistance. Thus, targeting GSCs is critical for o...

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Publicado no:Sci Transl Med
Main Authors: Shi, Yu, Guryanova, Olga A., Zhou, Wenchao, Liu, Chong, Huang, Zhi, Fang, Xiaoguang, Wang, Xiuxing, Chen, Cong, Wu, Qiulian, He, Zhicheng, Wang, Wei, Zhang, Wei, Jiang, Tao, Liu, Qing, Chen, Yaping, Wang, Wenying, Wu, Jingjing, Kim, Leo, Gimple, Ryan C., Feng, Hua, Kung, Hsiang-Fu, Yu, Jennifer S., Rich, Jeremy N., Ping, Yi-Fang, Bian, Xiu-Wu, Bao, Shideng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431250/
https://ncbi.nlm.nih.gov/pubmed/29848664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah6816
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