Targeting Glioma Stem Cell-derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy

The blood-tumor barrier (BTB) is a major obstacle for drug delivery to malignant brain tumors such as glioblastoma. Disrupting the BTB is therefore highly desirable, but complicated by the need to maintain the normal blood-brain barrier (BBB). Here, we show that targeting glioma stem cell (GSC)-deri...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Zhou, Wenchao, Chen, Cong, Shi, Yu, Wu, Qiulian, Gimple, Ryan C., Fang, Xiaoguang, Huang, Zhi, Zhai, Kui, Ke, Susan Q., Ping, Yi-Fang, Feng, Hua, Rich, Jeremy N., Yu, Jennifer S., Bao, Shideng, Bian, Xiu-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687837/
https://ncbi.nlm.nih.gov/pubmed/29100012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.10.002
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