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Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules
The remodeling of the microtubule cytoskeleton underlies dynamic cellular processes, such as mitosis, ciliogenesis, and neuronal morphogenesis. An important class of microtubule remodelers comprises the severases—spastin, katanin, and fidgetin—which cut microtubules into shorter fragments. While sev...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6431158/ https://ncbi.nlm.nih.gov/pubmed/30837315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818824116 |
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