Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (I(Ks)), which is essential for cardiac repolarization. Paradoxically,...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Zhou, Xin, Bueno-Orovio, Alfonso, Schilling, Richard J., Kirkby, Claire, Denning, Chris, Rajamohan, Divya, Burrage, Kevin, Tinker, Andrew, Rodriguez, Blanca, Harmer, Stephen C.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430739/
https://ncbi.nlm.nih.gov/pubmed/30967788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00259
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