Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternative to experimental assa...

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Detalles Bibliográficos
Publicado en:Front Physiol
Autores principales: Passini, Elisa, Britton, Oliver J., Lu, Hua Rong, Rohrbacher, Jutta, Hermans, An N., Gallacher, David J., Greig, Robert J. H., Bueno-Orovio, Alfonso, Rodriguez, Blanca
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601077/
https://ncbi.nlm.nih.gov/pubmed/28955244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00668
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