Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternative to experimental assa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Physiol
Prif Awduron: Passini, Elisa, Britton, Oliver J., Lu, Hua Rong, Rohrbacher, Jutta, Hermans, An N., Gallacher, David J., Greig, Robert J. H., Bueno-Orovio, Alfonso, Rodriguez, Blanca
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Physiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601077/
https://ncbi.nlm.nih.gov/pubmed/28955244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00668
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