Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

The dysregulation of Fbxo4-cyclin D1 axis occurs at high frequency in esophageal squamous cell carcinoma (ESCC), where it promotes ESCC development and progression. However, defining a therapeutic vulnerability that results from this dysregulation has remained elusive. Here we demonstrate that Rb an...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Qie, Shuo, Yoshida, Akihiro, Parnham, Stuart, Oleinik, Natalia, Beeson, Gyda C., Beeson, Craig C., Ogretmen, Besim, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428878/
https://ncbi.nlm.nih.gov/pubmed/30899002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09179-w
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