A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection, but how this binding event promotes the infection of host cells is unknown. Here, we employ protein NMR experiments supported by mass spectrometry and crystallography to study HBGA binding to the P-doma...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mallagaray, Alvaro, Creutznacher, Robert, Dülfer, Jasmin, Mayer, Philipp H. O., Grimm, Lena Lisbeth, Orduña, Jose Maria, Trabjerg, Esben, Stehle, Thilo, Rand, Kasper D., Blaum, Bärbel S., Uetrecht, Charlotte, Peters, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428809/
https://ncbi.nlm.nih.gov/pubmed/30899001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09251-5
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