Ex vivo conditioning with IL-12 protects tumor-infiltrating CD8(+) T cells from negative regulation by local IFN-γ

Optimal ex vivo expansion protocols for adoptive cell therapy (ACT) must yield T cells able to effectively home to tumors and survive the inhospitable conditions of the tumor microenvironment (TME), while simultaneously exerting persistent anti-tumor effector functions. Our previous work has shown t...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Immunother
Main Authors: Lin, Lin, Rayman, Patricia, Pavicic, Paul G., Tannenbaum, Charles, Hamilton, Thomas, Montero, Alberto, Ko, Jennifer, Gastman, Brian, Finke, James, Ernstoff, Marc, Diaz-Montero, C. Marcela
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428620/
https://ncbi.nlm.nih.gov/pubmed/30552459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2280-3
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