IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression

Lignende værker

• Modulation of immune cell infiltrate with sunitinib to improve anti-PD1 therapy in preclinical tumor model
  af: Rayman, Patricia, et al.
  Udgivet: (2015)
• Ex vivo conditioning with IL-12 protects tumor-infiltrating CD8(+) T cells from negative regulation by local IFN-γ
  af: Lin, Lin, et al.
  Udgivet: (2018)
• Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer
  af: Diaz-Montero, C Marcela, et al.
  Udgivet: (2015)
• Unraveling the nexus: Tumor-Infiltrating Lymphocytes (TILs), tumor stage and PD-L1 expression in colorectal carcinoma
  af: Abdal Ahmad, et al.
  Udgivet: (2025-09-01)
• Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
  af: Chacon, Jessica Ann, et al.
  Udgivet: (2014)