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IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes
Ribonucleotide reductase (RNR) supplies the balanced pools of deoxynucleotide triphosphates (dNTPs) necessary for DNA replication and maintenance of genomic integrity. RNR is subject to allosteric regulatory mechanisms in all eukaryotes, as well as to control by small protein inhibitors Sml1p and Sp...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428578/ https://ncbi.nlm.nih.gov/pubmed/25237103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1251550 |
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