Effects of the Arg9Cys and Arg25Cys Mutations on Phospholamban’s Conformational Equilibrium in Membrane Bilayers

Approximately, 70% of the Ca(2+) ion transport into the sarcoplasmic reticulum is catalyzed by the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), whose activity is endogenously regulated by phospholamban (PLN). PLN comprises a TM inhibitory region and a cytoplasmic regulatory region that harbors a co...

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Veröffentlicht in:Biochim Biophys Acta Biomembr
Hauptverfasser: Nelson, Sarah E. D., Ha, Kim N., Gopinath, Tata, Exline, Mara H., Mascioni, Alessandro, Thomas, David D., Veglia, Gianluigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428084/
https://ncbi.nlm.nih.gov/pubmed/29501609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.02.030
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